Fractures in shale: the significance of igneous intrusions for groundwater flow

Research in Cretaceous shales from West Africa has demonstrated that significant permeability can develop within shales at shallow depths (1 m day−1. Much of the variation in permeability is related to the degree of burial metamorphism, with shales that have been altered and that approach the anchizone having the highest permeability and those that are largely unaltered (early diagenetic zone) having the lowest permeability. However, further research targeting largely unaltered shales dominated by smectite clay has shown that the presence of small igneous intrusions can radically alter the hydrogeology. Twenty-four exploratory boreholes were drilled into smectite-dominated shale and nine of these boreholes were targeted to small dolerite intrusions within the shale. The dolerite was intensely fractured at the intrusion edge, with significant zeolite growth along the fracture surfaces. The permeability in the fractured dolerite was the highest measured in any shale borehole, with transmissivities of up to 60 m2 day−1 measured from pumping tests. Fracturing was less where dolerite was intruded into sandstones, however, and the measured transmissivity was lower (<0.5 m2 day−1). We postulate that the low permeability and high water content of the shale enabled high pressures to develop during intrusion, facilitating the development of fractures along the intrusion contact zone

B Decays on the Lattice and Results for Phenomenology

Lattice Monte Carlo simulations now include the effects of 2 light sea quarks and 1 strange sea quark through the use of an improved staggered fermion action. Consequently, results important to phenomenology are free of the approximate 10% errors inherent in the quenched approximation. This talk reports on calculations of the B and Bs decay constants and B -> pi l nu form factors. Accurate determinations of these quantities will lead to tighter constraints on CKM matrix elements.Comment: Contributed to the Proceedings of American Physical Society's 2004 Meeting of the Division of Particles and Fields (DPF2004), Riverside, CA, 26-31 August 2004. 3 page

Pathfinder cells provide a novel therapeutic intervention for acute kidney injury

Pathfinder cells (PCs) are a novel class of adult-derived cells that facilitate functional repair of host tissue. We used rat PCs to demonstrate that they enable the functional mitigation of ischemia reperfusion (I/R) injury in a mouse model of renal damage. Female C57BL/6 mice were subjected to 30 min of renal ischemia and treated with intravenous (i.v.) injection of saline (control) or male rat pancreas-derived PCs in blinded experimentation. Kidney function was assessed 14 days after treatment by measuring serum creatinine (SC) levels. Kidney tissue was assessed by immunohistochemistry (IHC) for markers of cellular damage, proliferation, and senescence (TUNEL, Ki67, p16ink4a, p21). Fluorescence in situ hybridization (FISH) was performed to determine the presence of any rat (i.e., pathfinder) cells in the mouse tissue. PC-treated animals demonstrated superior renal function at day 14 post-I/R, in comparison to saline-treated controls, as measured by SC levels (0.13 mg/dL vs. 0.23 mg/dL, p&#60;0.001). PC-treated kidney tissue expressed significantly lower levels of p16ink4a in comparison to the control group (p=0.009). FISH analysis demonstrated that the overwhelming majority of repaired kidney tissue was mouse in origin. Rat PCs were only detected at a frequency of 0.02%. These data confirm that PCs have the ability to mitigate functional damage to kidney tissue following I/R injury. Kidneys of PC-treated animals showed evidence of improved function and reduced expression of damage markers. The PCs appear to act in a paracrine fashion, stimulating the host tissue to recover functionally, rather than by differentiating into renal cells. This study demonstrates that pancreatic-derived PCs from the adult rat can enable functional repair of renal damage in mice. It validates the use of PCs to regenerate damaged tissues and also offers a novel therapeutic intervention for repair of solid organ damage in situ

Dynamics of Indian Ocean slavery revealed through isotopic data from the colonial era Cobern Street Burial site, Cape Town, South Africa (1750-1827)

The Dutch East India Company (VOC) intended the Cape of Good Hope to be a refreshment stop for ships travelling between the Netherlands and its eastern colonies. The indigenous Khoisan, however, did not constitute an adequate workforce, therefore the VOC imported slaves from East Africa, Madagascar and Asia to expand the workforce. Cape Town became a cosmopolitan settlement with different categories of people, amongst them a non-European underclass that consisted of slaves, exiles, convicts and free-blacks. This study integrated new strontium isotope data with carbon and nitrogen isotope results from an 18 th -19 th century burial ground at Cobern Street, Cape Town, to identify non-European forced migrants to the Cape. The aim of the study was to elucidate individual mobility patterns, the age at which the forced migration took place and, if possible, geographical provenance. Using three proxies, 87 Sr/ 86 Sr, δ 13 C dentine and the presence of dental modifications, a majority (54.5%) of the individuals were found to be born non-locally. In addition, the 87 Sr/ 86 Sr data suggested that the non-locally born men came from more diverse geographic origins than the migrant women. Possible provenances were suggested for two individuals. These results contribute to an improved understanding of the dynamics of slave trading in the Indian Ocean world

The B_s and D_s decay constants in 3 flavor lattice QCD

Capitalizing on recent advances in lattice QCD, we present a calculation of the leptonic decay constants f_{B_s} and f_{D_s} that includes effects of one strange sea quark and two light sea quarks. The discretization errors of improved staggered fermion actions are small enough to simulate with 3 dynamical flavors on lattices with spacings around 0.1 fm using present computer resources. By shedding the quenched approximation and the associated lattice scale ambiguity, lattice QCD greatly increases its predictive power. NRQCD is used to simulate heavy quarks with masses between 1.5 m_c and m_b. We arrive at the following results: f_{B_s} = 260 \pm 7 \pm 26 \pm 8 \pm 5 MeV and f_{D_s} = 290 \pm 20 \pm 29 \pm 29 \pm 6 MeV. The first quoted error is the statistical uncertainty, and the rest estimate the sizes of higher order terms neglected in this calculation. All of these uncertainties are systematically improvable by including another order in the weak coupling expansion, the nonrelativistic expansion, or the Symanzik improvement program.Comment: 4 page

Morphologies and Color Gradients of Luminous Evolved Galaxies at z~1.5

We have examined in detail the morphologies of seven z~1.5 passively evolving luminous red galaxies using high resolution HST NICMOS and ACS imaging data. Almost all of these galaxies appear to be relaxed systems, with smooth morphologies at both rest-frame UV and visible wavelengths. Previous results from spectral synthesis modeling favor a single burst of star formation more than 1 Gyr before the observed epoch. The prevalence of old stellar populations, however, does not correlate exclusively with early-type morphologies as it does in the local universe; the light profiles for some of these galaxies appear to be dominated by massive exponential disks. This evidence for massive old disks, along with the apparent uniformity of stellar age across the disk, suggests formation by a mechanism better described as a form of monolithic collapse than as a hierarchical merger. These galaxies could not have undergone a single major merging event since the bulk of their stars were formed, more than 1 Gyr earlier. There is at least one case, however, that appears to be undergoing a "dry merger", which may be an example of the process that converts these unusual galaxies into the familiar spheroids that dominate galaxies comprising old stellar populations at the present epoch.Comment: 16 pages, 9 figures (8 in color), accepted for publication in Ap

The COMMAND trial of cognitive therapy for harmful compliance with command hallucinations (CTCH) : a qualitative study of acceptability and tolerability in the UK

Objectives To explore service user experiences of a 9-month cognitive behavioural therapy for command hallucinations in the context of a randomised controlled trial including their views on acceptability and tolerability of the intervention. Design Qualitative study using semistructured interviews. Setting The study took place across three sites: Birmingham, Manchester and London. Interviews were carried out at the sites where therapy took place which included service bases and participants’ homes. Participants Of 197 patients who consented to the trial, 98 received the Cognitive Behavior Therapy for Command Hallucinations (CTCH) intervention; 25 (15 males) of whom were randomly selected and consented to the qualitative study. The mean age of the sample was 42 years, and 68% were white British. Results Two superordinate themes were identified: participants’ views about the aspects of CTCH they found most helpful; and participants’ concerns with therapy. Helpful aspects of the therapy included gaining control over the voices, challenging the power and omniscience of the voices, following a structured approach, normalisation and mainstreaming of the experience of voices, and having peer support alongside the therapy. Concerns with the therapy included anxiety about completing CTCH tasks, fear of talking back to voices, the need for follow-up and ongoing support and concerns with adaptability of the therapy. Conclusions Interpretation: CTCH was generally well received and the narratives validated the overall approach. Participants did not find it an easy therapy to undertake as they were challenging a persecutor they believed had great power to harm; many were concerned, anxious and occasionally disappointed that the voices did not disappear altogether. The trusting relationship with the therapist was crucial. The need for continued support was expressed